Assessment of Efficiency of Bioactive Glass, Self-Assembling Peptide, and Ozone Remineralising Agents on Artificial Carious Lesion

ABSTRACT Objective: To assess the efficacy of bioactive glass, self-assembling peptide, and ozone-remineralizing agents on the artificial carious lesion. Material and Methods: On the extracted 60 premolar teeth, an artificial carious lesion/demineralization was created. Later, the remineralization of demineralized teeth was done with respective remineralizing agents (Group A: Calcium sodium phosphosilicate (bioactive glass), Group B: Self-assembling peptide, Group C: Ozone remineralizing agents and Group D (Control): De ionized water. The degree of demineralization and remineralization were evaluated using the Vickers Hardness Number. Results: There was a decrease in microhardness from baseline to demineralization in all the groups, and this reduction was found to be statistically considerable. After the remineralization of demineralized samples with respective remineralizing agents, there was an increase in microhardness of 312.38, 276.67, and 254.42 in groups A, B, and C, respectively. In contrast, in Group D, there were no changes. Conclusion: Bioactive glass and self-assembling peptides had higher remineralizing capacities, which can be used to treat early carious lesions.

Radical cystectomy in patients with transitional cell carcinoma urinary bladder

Objective:To find out various presentations, types of operations performed, perioperative complications, pathological staging and oncological outcome of patients with transitional cell carcinoma [TCC] urinary bladder treated with radical cystectomy

Study design: Descriptive case series

Place and Duration of study: Department of Urology Jinnah Postgraduate Medical Centre Karachi, from January 2009 to December 2014

Methodology: All patients who underwent radical cystectomy with bilateral pelvic iliac lymphadenectomy due to muscle invasive transitional cell carcinoma of bladder with or without adjuvant or neo-adjuvant chemotherapy or radiotherapy from January 2009 to December2014 with minimum of two years follow up, were included in the study. Patients with proven metastasis were excluded. Clinical presentations, details of surgeries, post-operative complications, pathological staging and oncological outcomes were recorded

Results: Thirty-two patients were operated. Age ranged from 35 to 70 year. There were.28 males [87.5%] and 04 females [12.5%] patients. Painless hematuria was the most common clinical presentation. Most [81.2%] of the patients were diagnosed as muscle invasive transitional cell carcinoma on first trans-urethral resection of bladder growth [TURBT]. Radical cystectomy with standard pelvic lymph node dissection [PLND] and ileal conduit were performed in all patients. Two [6.2%] patients died in perioperative period. Fourteen [43.8%] patients developed complications. Pathological staging revealed non-organ confined disease with positive lymph node in six [18.6%] patients. Disease free survival [DFS] was noted in 68.7% of patients. Over-all survival was 65.6%

Conclusion: Radical cystectomy in patients with potentially invasive or invasive TCC bladder helped in achieving long term survival in majority of the patients

Comparison of central corneal thickness measurements with the galilei dual scheimpflug analyzer and ultrasound pachymetry

Objective: To determine the correlation between mean central corneal thickness taken with Galilei dual Scheimpflug Analyzer and Applanation Ultrasound Pachymetry

Study Design: Descriptive cross sectional study

Place and Duration of Study: Armed Forces Institute of Ophthalmology Rawalpindi, from Jul 2013 to Jan 2014

Material and Methods: Central corneal thickness was measured in 100 eyes of 50 patients. First three readings were taken with Galilei dual Scheimpflug analyzer, with a gap of 1 minute. Then three readings were taken with ultrasound pachymetry after applying topical 0.5% proparacaine [Alcain]. The mean of the three readings was used for the analysis

Results: For right eye the mean central corneal thickness measured by the Galilei dual Scheimpflug analyzer and Ultrasound pachymetry was 544.06?m +/- 27.36 and 546.88?m +/- 27.71 respectively, and for left eye it was 544.72?m +/- 25.47 and 546.52?m +/- 26.15 respectively. There was a strong and positive correlation between the two instruments [r=0.969, p=0.000 for right eye and r=0.956, p=0.000 for left eye]

Conclusions: The pachymetry readings with GSA showed strong and positive correlation with those of US pachymetry. So GSA may be considered as an alternative to US Pachymetry, thus avoiding operator-dependent errors, patient discomfort and other disadvantages

Double J stent removal by trained operation theater nurse under topical anesthesia in female patients

Objective: to document outcome of DJ stent removal by trained operation theater nurse under topical anesthesia in female patients

Study design: descriptive study

Place and Duration of study: department of Urology Jinnah Postgraduate Medical Center, Karachi from June 2015 to February 2016

Methodology: Female patients, for DJ stent removal, who did not give consent for the procedure to be performed by the male doctors, were included. Patients in whom DJ stent placement duration was more than 4 months with radiological evidence of encrustation and those in whom ureteric re-implantation done, were excluded. All double J Stents were removed by trained female senior theater nurse under supervision of consultant urologists. All operative and postoperative problems were recorded

Results: a total of 30 patients underwent DJ stent removal during the study period. Age of the patients ranged from 15 year to 55 year. Mean age was 27 year. Most common indication for DJ stent placement was obstructive renal stones in 36.6%. Out of the total two patients required general anesthesia and ureteroscopy for its removal. In one case there was encrustation around DJ stent and in other patient it was due to broken DJ stent. Minimal complications were noted in follow-up

Conclusion: it was safe to assign the task of DJ stent removal to the female nurse after adequate training. This produced was suited for female patients reluctant to have this procedure done by male doctors in a conservative society like Pakistan

Laparoscopic surgery in urology: an experience from a tertiary care center

Objective: To describe the results of laparoscopic procedures performed in a Urology unit of a tertiary care hospital

Study design: Case series

Place and Duration of study: Department of Urology Jinnah postgraduate Medical Centre Karachi, from March 2011 to February 2016

Methodology: Data of all planned laparoscopic surgeries were collected and analyzed for demographic information, laboratory reports, procedure details, operative time, duration of hospital stay, complications and follow up details. BAUS guidelines were used to learn laparoscopic skills. Data was analyzed using Statistical package for the social Sciences [SPSS, Version 20.0]

Results: There were total of 57 patients who underwent laparoscopic surgery. This included 48 males [84.21%], and 9 [15.7%] females. Mean age of patient was 30.37 +/- 12.01 year [Range 12-73 year]. The procedures performed included simple nephrectomy [n=13], ureterolithotomy [n=14], varicocelectomy [n=13], orchidopaxy [n=2]. There were 12 diagnostic procedures for non-palpable testes, one adrenalectomy, one radical cystectomy, and one vesico-vaginal fistula repair. Fifteen patients needed conversion to open surgery due to various reasons. Out of 42 successfully performed laparoscopic procedures 10 different complications were noted majority being Clavien Grade II, including blood transfusion in one patient

Conclusion: Laparoscopic surgery has a prolonged learning curve. The conversion rate in this study was 26.3%

Seroprevalence and Spatial Distribution of Toxoplasmosis in Sheep and Goats in North-Eastern Region of Pakistan

Toxoplasmosis is a protozoan disease that is caused by Toxoplasma gondii in livestock and humans. Due to its medical and veterinary importance, it is essential to study the seroprevalence of T. gondii infection among humans and animals in various parts of the world. The major objective of this study was to determine the seroprevalence and spatial distribution of toxoplasmosis in small ruminants (sheep and goats) of north-eastern region, Pakistan. A total of 1,000 animals comprising of sheep (n=470) and goats (n=530) were examined for T. gondii infection by using ELISA. An epidemiological data was collected in the form of questionnaire. A surface has been generated by using method of interpolation in Arc GIS with the help of IDW (inverse distance weight). The results showed higher seroprevalence of T. gondii in goats (42.8%) as compared to sheep (26.2%). The seroprevalence was higher in females as compared to males in all examined ruminants. Similarly, there is a wide variation in the seroprevalence of T. gondii in different breeds of sheep and goats showing higher seroprevalence in Teddy (52.8%) and Damani breed (34.5%) of goat and sheep's, respectively. The geographical and spatial distribution of T. gondii shows that it is widely distributed in different parts of the north-eastern region of Pakistan. Our results suggest widespread environmental contamination with T. gondii oocysts. It suggests us that small ruminants could be a potentially important source of T. gondii infection if their infected meat is consumed undercooked.

Morphological variants of renal carcinoma in radical nephrectomy specimens

To determine the morphological variants of Renal Cell Carcinoma [RCC] to detect the commonest histopathological type with special focus to the newly introduced entity Clear Cell Papillary Renal Cell Carcinoma [CCPRCC]. Case series. Department of Pathology, Basic Medical Sciences Institute, JPMC, Karachi, from January 2007 to December 2012. Paraffin embedded blocks of 32 cases of radical nephrectomy specimens for renal mass were selected from records of Pathology Department, BMSI. Cases were excluded due to inadequate biopsies. Remaining 30 cases of renal cell carcinoma were included in study. H and E staining was done for all cases and PAS stain was employed for a few cases. All cases were reviewed under light microscope. The 30 cases of renal cell carcinoma included 21 [70%] clear cell renal cell carcinoma, 03 [10%] clear cell papillary renal cell carcinoma, 02 [6.6%] papillary renal cell carcinoma and 04 [13.33%] hybrid tumors. Majority of cases [53.3%] found in age range between 40 - 60 years while 23.33% cases were found in 7th and 6.6% in 8th decade of life. While 16.66% cases were in younger age group that is between 31 - 40 years of age. Sixty percent cases of right radical nephrectomies and 40% cases of left radical nephrectomies. CCRCC was most common histopathologic type followed by CCPRCC, hybrid tumors and PRCC

Primary isolated renal hydatid cyst simulating renal malignancy

Renal hydatid disease occurs in only 2 to 3 percent of cases. Primary isolated renal hydatid cyst is an extremely rare manifestation. A case of 20 year old male is reported who presented with left lumbar pain and weight loss. Preoperative diagnosis was renal malignancy. During surgery renal hydatid cyst was found

Prevalence of domestic violence among pregnant women visiting federal general hospital Islamabad

To Estimate prevalence of domestic violence and associated risk factors among pregnant women attendingthe Federal General Hospital, Islamabad. Descriptive cross sectional study. This research was conducted in the Federal General Hospital, Islamabad from May 2014 to October 2014. A descriptive cross sectional survey was carried out on 150 pregnant women by employing systematic sampling. Pregnant women without any serious medical complication were selected for study. Standardized, pretested, domestic violence questionnaire based on PDHS 2012-2013 was used to assess domestic violence during pregnancy. A SPSS version 16.0 was used for data entry and analysis. Descriptive analysis of all categorical variables in form of frequencies and percentages along with binary logistic regression wasapplied. Overall, [24.3%] women experienced one form of abuse, answering yes to at least one of the five domestic violence questions. This study demonstrated the educational level of pregnant women; income, parity, year since married and women empowerment were significantly [p<0.001] associated with presence of domestic violence. Parity was a strong predictor of physical abuse [p<0.001; OR=2.8,95%CI=1.3-3.6]. Women who belong to low socio-economic income [<10,000/month] were at significantly high risk [p<0.001: OR=1.5, 95%CI=0.9-3.3] of physical abuse as compared to women with middle and high income [20,000-50,00/month] . Prevalence of domestic violence among pregnant women is very high in our part of the world. The statistically significant associated risk factors with the domestic violence are low educational level of pregnant women along with low income, parity, and poor socio-economic status

Out of pocket cost born by patients of type 2 diabetes mellitus in private diabetic clinics of islamabad

To estimate the direct cost and its determinants in type2 diabetic patients visiting outpatient department of private tertiary care hospitals. A descriptive cross sectional study. This research was carried out in the diabetic outpatient department of Shifa international hospital and AN medical Centre from 15 November 2014 to 15 February 2014. The descriptive cross sectional study was conducted on 108 diabetic patients [male 52%, female 54%]. By employing simple random sampling technique the data was collected from patients having diabetes from at least 5 years, with age limit between 30 to 80 years, with or without having complications through pretested interview administered questionnaire. The structured questionnaire was used for collecting data. SPSS 20.0 was used forrflata analysis. The percentages and frequencies were drawn in order to draw the results. The results showed that the average direct cost spent by a patient was 7704 PKR per month. More than half [66.7%] of the study subjects have suffered from diabetes since 5-10years. A larger group of respondents [50%] was treating diabetes with oral hypoglycemic. Medication, consultation, and lab investigation charges were the main determinants of diabetic cost. Per month medication charges were 3997 PKR, followed by lab investigation charges of 2441PKR per visit and consultation cost was 1298 PKR. Most of the patients [86.1%] were having one complication due to diabetes. The cost of treatment increased with the increasing age and morbidities. Diabetes is very expensive disease to manage. The affluent charges of managing diabetes and its day by day increased cases will put tremendous burden on the society

Gastroesophegeal reflex disease [GERD] and dental erosion

Gastroesophageal reflux [GER] is the passage of gastric contents into the esophagus, and GERD is defined as symptoms or complications of GER. The most common extra oral manifestation of GERD is tooth surface loss, a progressive, irreversible loss of dental hard tissues due to a chemical process not involving bacteria. Dentists are often the first health care personnel to diagnose dental erosion in patients with gastroesophageal reflux disease [GERD]. Permanent incisors and first permanent molars of 210 patients having age 06 years and above were examined. Patients were asked to fill the questionnaire containing questions about previous history of gatroesophageal reflex disease. Community periodontal index and treatment need [CPITN] probe was run over labial, occlusal and lingual surfaces of incisors and molars, to check for loss of enamel surface. Out of 210 patients examined, 39 were [18.57%] having GERD. Out of 39 patients only one [2.56%] patient had less than one third of the enamel surface involved. 13[33.3%] patients should teeth between one third and two third of the surface involved. 14[35.9%] patients had more than two third surface involved and in 6[15.4%] patients, assessment was not possible. Gatroesophageal reflex disease [GERD] is an increasingly common and potentially serious condition, with various extraesophageal adverse health effects that dental practitioners should be aware of. Clinicians should also be aware of the predisposing risk factors for GERD and its classical esophageal and extraesophageal symptoms and signs. This study determined the GERD patients were at higher risk of developing dental erosion compared to the healthy individuals in a sample of Pakistani population

Frequency and distribution of dental caries in teeth and arches of patients examined at Punjab Dental Hospital, Lahore

Worldwide prevalence of dental caries is very high reaching to more than 95% in developing countries. . Dental caries is a multi-factorial, dynamic and infectious microbiologic disease process resulting from imbalance in the physiologic equilibrium between the tooth mineral and the plaque liquid. The study design was cross-sectional. This study aim was to evaluate the frequency and distribution of dental caries in teeth and arches of caries patients reporting to department of Operative dentistry at Punjab Dental Hospital, Lahore. Total of 15323 patients with caries reporting to the OPD of Operative dentistry at Punjab Dental hospital were examined with age range of 10 to 60 years or more. Frequency of carious teeth in age group 20-29 years was maximum and minimum in age group 60 years or more. Dental caries was more prevalent in mandible [53%][n=8162] than in maxilla[47%] [n=7158]. In both the arches, first molars were the most frequently affected teeth by caries. Caries was found to be more prevalent in mandible than maxilla

Comparing the effects of osteoporosis prevention exercise protocol [OPEP] versus walking in the prevention of osteoporosis in younger females

The aim of this work was to evaluate the effectiveness of Osteoporosis Prevention Exercise Protocol [OPEP] in younger females. One hundred young female volunteers aged 20-30 were selected from IPM and R Dow University of Health Sciences. This was a comparative study in which 64 females participants were randomly assigned into two groups [32 in OPEP exercise group and 32 in walking group]. The exercise session had three components 1] stretching 2] strengthening 3] high impact weight bearing exercises. Both interventional programs consisted of 3 sessions per week for twelve weeks under the supervision of physiotherapist. Pre and post intervention bone mass density [BMD] was measured on the lumbar spine [L1-L4], hip, femur, and distal forearm by using Dual-Energy X-ray Absorptiometry [DEXA] scan. After twelve weeks of intervention BMD was found to be statistically insignificant at hip, femur, lumbar spine and wrist [p > 0.05] comparing the post results in the OPEP and exercise group. Moreover BMD at hip, femur, lumbar spine and wrist was unaltered in both groups comparing the results of pre and post intervention. Though significant changes were observed in BMI in the OPEP exercise group [p value =0.010] mean +/- standard deviation pre and post found to be 20.2578 +/- 3.11123 and 21.0942 +/- 3.64203 but no variations in anthropometrics in walking group were found. The present study highlights the burden of osteopenia in younger females. The Osteoporosis Prevention Exercise Protocol formulated by author was not useful to bring any significant changes in BMD moreover it had no significant effects in comparison to walking group. However additional studies are needed to evaluate the efficacy of Osteoporosis Prevention Exercise Protocol on bone quality with long term effects

Delayed single stage perineal posterior urethroplasty

To determine the delayed single stage perineal posterior urethroplasty for treatment of posterior urethral stricture/distraction defect. Descriptive case series. Department of Urology, Jinnah Postgraduate Medical Centre, Karachi, from January 2009 to December 2011. Patients were selected for delayed single stage perineal posterior urethroplasty for treatment of posterior urethral stricture / distraction defect. All were initially suprapubically catheterized followed by definitive surgery after at least 3 months. Thirty male patients were analyzed with a mean follow-up of 10 months, 2 patients were excluded as they developed failure in first 3 months postoperatively. Mean patient's age was 26.25 +/- 7.9 years. On follow-up, 7 patients [23.3%] experienced recurrent stricture during first 10 months. Five [16.6%] patients were treated successfully with single direct visual internal urethrotomy. Two patients [6.6%] had more than one direct visual internal urethrotomy and considered failed. Re-do perineal urethroplasty was eventually performed. The overall success rate was 93.3% with permissive criteria allowing single direct visual internal urethrotomy and 76.6% with strict criteria allowing no more procedures postoperatively. Posterior anastomotic urethroplasty offers excellent long-term results to patients with posterior urethral trauma and distraction defect even after multiple prior procedures

Role of manual therapy with exercise regime versus exercise regime alone in the management of non-specific chronic neck pain

To evaluate the role of manual therapy with exercise regime versus exercise regime alone in the management of non-specific chronic neck pain. In this 62 subjects randomized controlled trial 31 subjects in group A received manual therapy [manipulation] with supervised exercise regime whilst 31 subjects in group B performed only supervised exercise regime for the period of 3 weeks. Both groups had a home exercise program consisted of strengthening exercises for neck/scapuluar stability, stretching and general range of motion exercises for neck with advice regarding posture awareness and correction for 3 months. The results suggested significant reduction in pain intensity level in both groups; over 3 weeks and 12 weeks' time period in relation to baseline on visual analog scale [p=0.001]. Similarly, statistically significant improvements noticed in Neck Disability Index [NDI] [p=0.0001] in both groups while looking at baseline data with reference to 12 weeks' time period. On closer inspection, the manual therapy [manipulation] with exercise regime appeared as a favorable treatment preference compared with exercise regime alone

Outcome of percutaneous Nephrolithotomy

To assess the implementation of Percutaneous Nephrolithotomy [PCNL] in renal stone management and evaluate the factors for efficacy and safety of PCNL. Case series. Department of Urology at Jinnah Postgraduate Medical Centre, Karachi, from January 2008 to December 2011. Patients aged above 12 years of age, irrespective of gender with normal renal function, mean stone size > 2 cm, lower pole stones > 1 cm, and ESWL failure were selected. After the procedure, on the first postoperative day, a plain abdominal radiograph was obtained to verify stone clearance. A nephrostomy tube was clamped overnight and subsequently removed when no residual stone which needs second sitting was seen. In 175 patients, 62.86% [n=110] were male and the mean age was 35 +/- 9.56 years. One hundred and seventeen [66.85%] patients were primarily stone free and 13.71% [n=24] patients needed a second look procedure, thus, a total of 80.57% [n=141] patients were stone free in the same admission. Complications included failure in 4.0% [n=7] patients, bleeding in 8.57% [n=15] patients, a small residual stone in 15.43% [n=27] patients; and puncture site pain almost in every patient. Transient fever occurred in 55.43% [n=97] patients, urinary leakage in 8.57% [n=15] patients, urinary tract infections in 5.14% [n=9] patients, ureteric colic in 3.43% [n=6] patients, colonic injury in 0.57% [n=1] patient; and nephrectomy was required in 0.57% [n=1] patient due to severe bleeding. One patient [0.57%] expired due to anaesthesia complications. Percutaneous nephrolithotomy [PCNL] has a good success rate. There is minimal blood loss, and few major complications.

Expression of von hippel - lindau [VHL] gene mutation in diagnosed cases of renal cell carcinoma

To evaluate the expression of Von Hippel Lindau [VHL] gene in diagnosed cases of renal cell carcinoma. This cross sectional study was conducted in department of Pathology, Basic Medical Sciences Institute, JPMC, Karachi, from January 2007 to December 2012. Paraffin embedded blocks of 30 cases of radical nephrectomy specimens diagnosed as renal cell carcinoma including CCRCC 21 [70%] CCPRCC, 3 [10%], PRCC 2 [6.79%], hybrid tumor 4 [13.3%], chromophobe tumor [0%] processed for VHL gene expression on Polymerase Chain Reaction. All the 30 cases previously diagnosed as renal cell carcinoma were processed on PCR, VHL gene mutations were seen in 20 [95.23%] of CCRCC while a single case was negative for VHL mutations. All CCPRCC were negative for VHL mutation. Among the hybrid tumor 03 cases with foci of clear cells show VHL mutation while a single case showing combination of clear cells and chromophobe cells was negative for mutation. Both the cases of PRCC were positive for mutation. Exon 3 mutation at base pair 194 seen in 8 [32%] cases and Exon 2 mutation at base pair 150-159 seen in 17 [68%] cases. None of the cases showed Exon 1 mutation. The present study shows that majority of CCRCC showed VHL mutation including the hybrid tumor with clear cell component in our population

Open dismembered pyeloplasty for uretero-pelvic junction obstruction

To report our experience with open dismembered pyeloplasty for uretero-pelvic junction obstruction. Retrospective study was conducted in the Department of Urology, Jinnah Postgraduate Medical Centre, Karachi for a period of five and half years from May, 2006 to December, 2011. All patients with uretero-pelvic junction obstruction were entered into a database to record patients clinical features, diagnostic tools, operative and post-operative details and follow-up. Over a five-years period, 13 procedures were performed. After clinical evaluation all patient had extensive haematological and radiological workup for diagnosis of uretero-pelvic junction obstruction. All were subjected to open pyeloplasties, out of these 13 patients; one had an aberrant lower pole vessel compressing uretero-pelvic-junction. All procedures were stented. Repair was done with 3/0 vicryl sutures all patients were catheterized and wound drained. Mean operating time was 60 - 100 minutes with about 100cc blood loss requiring no transfusion. The mean follow up was one year. One patient developed post-operative haematuria and was managed conservatively. Two patients developed fever secondary to urinary tract infection despite adequate treatment of urinary tract infection according to culture and sensitivity pre-operatively. One patient developed surgical emphysema detected post-operatively, which required tube thoracostomy. Neither patient developed recurrent symptoms nor had any evidence of obstruction on the renogram on follow-up. Objectively all patients were followed up by intravenous urogram, stress renogram, Urine C/S. Subjective and objective follow-up revealed success in 100% of patients whereas success is defined as no or minimal holder on DTPA renogram, improving renal function and decreasing dilatation on successive intravenous urogram. All patients had a mean post-operative hospital stay of 02 - 04 days Folley catheter was removed after 10-days, double-j- stents were removed after two to three weeks. Our success rate following open pyeloplasty with limited follow-up was 100%. It is comparable with International data. Recent international trend is toward Uretro-pelvic Junction Obstruction [UPJO] repair with laparoscopic approach, they are claiming success rate of 95%

Intensity of dental erosion in age groups [childhood, adolescence and adults]

The aim of this study was to find out correlation between dental erosion and its impact on different age groups. It is often difficult to compare the outcomes of different epidemiological studies on dental erosion due to the use of different examination standards, including scoring systems, samples and groups examined. Permanent incisors and first permanent molars of 210 patients having age 06 years and above were examined for dental erosion. Community periodontal index and treatment need [CPITN] probe was run over labial and lingual surfaces of incisors and buccal and lingual surfaces of molars, to check for loss of tooth surface. Patients were divided into three groups on the basis of age. i.e. Group I [06 years to 12 years], Group II [13 years to 18years] and Group III [19years and above]. Results collected on a Tooth Wear Index [TWI] showed that there was a non significant association between age of the patient and erosion as it was equally distributed among patients of all ages. The rationale of this study was to find out correlation between dental erosion and its impact on different age groups

Effectiveness of core stabilization exercises versus Mckenzie's exercises in chronic lower back pain

To determine the effectiveness of core stabilization and McKenzie's exercises on intensity of pain, disability and lumbo-pelvic stability was compared in non-specific chronic low back pain [CLBP] patients. Randomized controlled trial study. This study was conducted at Departments of Physical Therapy, Institute of Physical Medicine and Rehabilitation, Dow University of Health Sciences Karachi and Peoples University of Medical and Health Sciences, Nawabshah during 2012-13. Thirty patients with non-specific CLBP were enrolled through convenience sampling and were randomly assigned core stabilization and McKenzie exercises. Intensity of pain, disability, and lumbo-pelvic stability were evaluated by Visual Analouge Scale, The Oswestry disability Questionnaire, and Stibilizer Pressure Biofeedback Unit, respectively. Eighteen sessions were done for both groups. T-tests and ANCOVA test were used for statistical analysis [p<0.05]. Although the score of pain decreased in both groups [p<0.05], the decrease of intensity of pain was more than in Core Stabilization Exercises Group [p<0.05]. The score of disability questionnaire decreased in stabilization exercise group [p<0.05]. During Knee Lift Abdominal and Bent Knee Fall Out maneouvres, pressure of biofeedback unit did not significantly differ before and after interventions, in both groups [p>0.05]. The stabilization exercises can reduce pain and disability in nonspecific CLBP patients